Liu et al. (2022) found that circ-0026218 attenuates oxLDL-induced inhibitory effects on cell proliferation and apoptosis in HUVECs by regulating the miR-188-3p/TLR4/NF-κB pathway. Xiong et al. (2021) discovered that knocking out circNPHP4 in exosomes derived from monocytes might inhibit heterotypic adhesion of monocytes and coronary artery endothelial cells by reducing miR-1231, potentially through interactions within the circNPHP4/miR1231/EGFR axis. These studies all indicate that reducing inflammatory responses has a protective effect on the development of atherosclerosis (Fig. 3). Here, NFKB1 is linked to atherosclerosis.