To elucidate the roles of 15 key genes (RPS6KA3, CTSD, NCAM1, CREG1, CPVL, TNFRSF1A, PECAM1, IL7R, ZNF101, RRM2B, MARCKSL1, MCM3, ATP7A, MAP2K4, and TNC) within the GSE143272 dataset, a differential expression analysis was conducted comparing the epilepsy and control cohorts. This evidence concerns the gene RPS6KA3 and epilepsy.