CD40LG and cancer: Levels of immunoglobulin (Ig)G, IgG1, IgG4, and IgM were evaluated pre and post a TTd-containing vaccination in prostate cancer patients to confirm that they mount anti-MTTE antibodies similar to healthy volunteers as reported in Fletcher et al.18Prostate cancer patients displayed significantly increased levels of IgG, IgG1, and IgG4, but not IgM after the TTd vaccination (Figures 2A–2D).