TGFB1 and neoplasm: Finally, a dual-responsive micellar system (PEG-PLL-DMMA/P(HCPT-DTDA)-PEI) co-delivering siTGF-β and hydroxycamptothecin undergoes size shrinkage and charge reversal in acidic TME, improving tumor penetration, reducing immune tolerance, and reprogramming the tumor microenvironment via EMT inhibition and TGF-β blockade [78].