In HFD group, Masson’s trichome stain intensity increased 6.8-folds, indicating the onset of liver fibrosis; ROS generation and lipid peroxidation (TBARS) were significantly (p < 0.01) increased, whereas SOD and CAT were decreased by 36.7 % and 49.7 %, respectively. Here, SOD1 is linked to Hepatic fibrosis.