Growing evidence has suggested that chronic inflammation is one of the possible promoting factors for esophageal cancer development, particularly EAC,51,52 IL-33, as a proinflammatory cytokine, may play an important role in the induction of inflammation in esophagus,14,48 and is involved in esophageal cancer initiation, invasion, and metastasis.8 Liu et al.17 report that the population of IL-33-positive cells in human EAC tumor tissues (n = 63) is higher than that in adjacent control tissues. Here, IL33 is linked to esophageal cancer.