Studies showed that elevated levels of IL-33 correlated with the invasion, progression, and metastasis in human ESCC32 by enhanced recruitment of Tregs,19 pro-angiogenesis,20 and polarization of macrophages toward the M2 subtype.67 EAC is another common histological type of esophageal cancer seen in the Western world. This evidence concerns the gene IL33 and esophageal cancer.