Interestingly, studies have found that GERD and EoE share an overlap of clinical features,84 in which GERD may cause the development of EoE, and vice versa.85 Thus, it has been postulated that the IL-33/ST2 axis could be involved in the immunopathogenesis of GERD15,17 and targeting the IL-33/ST2 signal and relevant downstream elements may reduce the process of esophageal inflammation and symptoms in GERD.31 The gene discussed is IL33; the disease is gastroesophageal reflux disease.