In the absence of proinflammatory stimuli, IL-33 is usually expressed in the nucleus.2,23 However, the relocation of IL-33 from the nucleus to the cytoplasm has been observed.24 For example, the expression of IL-33 in the cytoplasm is increased in the AGS gastric cancer cell line in response to adequate Helicobacter pylori stimulation.25 In EAC animal models, Liu et al.17 reported that IL-33 immunoreactivity is localized in the cytoplasm of EAC cells. This evidence concerns the gene IL33 and gastric cancer.