While IL-33 is expressed in ESCC cells, it is predominantly expressed in the nucleus of ESCC cells.18 Such translocation from the nucleus to the cytoplasm may reflect that extracellular release of IL-33 synthesized in the cell nucleus must pass through the cytoplasm to the outside of the cell.24,26 However, the precise mechanism and significance of IL-33 translocation remain to be investigated. The gene discussed is IL33; the disease is esophageal squamous cell carcinoma.