Regarding lung microbiota functionality, the abundances of four signaling pathways—Wnt (ko04310), Notch (ko04330), chronic myeloid leukemia (ko05220), and MAPK-yeast (ko04011)—were strongly negatively correlated with serum IL-1β and IL-10 levels, suggesting that these pathways may play a role in the interaction between the lung microbiota and host immunity (Tian et al., 2022). Here, IL1B is linked to chronic myelogenous leukemia, BCR-ABL1 positive.