HSD3B7 and cancer: Furthermore, we discovered that the induction of BAs caused by the forced expression of HSD3B7 promoted cancer cell growth and proliferation and defined that HSD3B7 was frequently upregulated in the paracancerous tissues of HCC patients, suggesting the potential oncogenic activity of HSD3B7 and its potential application in cancer therapy, which was in accordance with the recent study about the essential function of HSD3B7 in ccRCC cell survival.35