HSD3B7 and cancer: More importantly, in vitro study showed that supernatants from either miR-122 overexpression or HSD3B7 knockdown reduced the DNA replication of cancer cells, whereas HSD3B7 overexpression, administration of TCA, or supernatants from miR-122 antagonism promoted cancer cell growth, suggesting that abnormal accumulation of BAs by miR-122 deficiency may act as hepatomitogens to facilitate cancer cell proliferation.