MYC and neoplasm: Strikingly, we observed rapid outgrowth of multifocal c-Myc/sgTP53-induced and AKT/β-catenin-induced liver tumors in LKO mice, showed by significantly elevated tumor number, tumor size, and liver/body weight ratio and increased tumor incidence (Figures 5C and 5D), compared with CTRL mice, suggesting that miR-122 deficiency in hepatocytes synergizes with oncogene activation to promote HCC development.