A study by Fan et al. (34) demonstrated that the effects of high-intensity RT compared to medium-and low-intensity RT on HOMA-IR in patients with Type 2 Diabetes Mellitus were distinct, with only medium-and low-intensity RT resulting in a significant decrease in HOMA-IR, which suggests enhanced insulin sensitivity and lowered systemic inflammation, leading to lower energy intake. Here, INS is linked to type 2 diabetes mellitus.