The major producer of IL-4 in helminth infection is Th2-Tfh (Chen et al., 2014; King & Mohrs, 2009; Zaretsky et al., 2009), which are indispensable in antibody-associated control of malaria (Pérez-Mazliah et al., 2017; Soon et al., 2021). This evidence concerns the gene IL4 and malaria.