For example, in 2021, Kim's team analyzed the whole exome sequencing (WES) data of 47 EOCRC patients and targeted deep sequencing data of 833 CRC cases, and found that TP53 dysfunction leads to whole genome doubling (WGD) and amplification of oncogenes, thereby forming a unique genomic evolutionary path, which may also be a key factor in the onset of EOCRC (Kim et al., 2021). Here, TP53 is linked to colorectal carcinoma.