For example, Campos Segura et al. (2023) showed through the analysis of CRC data in the cBioPortal database that DOCK3, FN1, PAPPA2, DNAH11, and FBN2 are mini-drivers of CRC progression, and are associated with poor prognosis of CRC (Campos Segura et al., 2023). This evidence concerns the gene PAPPA2 and colorectal carcinoma.