IL1F10 and rheumatoid arthritis: Binding to IL-36R or IL-1RAPL1 receptors, IL-38 triggers a signaling cascade involving Toll and interleukin-1 receptor (TIR), RohA, ERK, JNK, and p38, which in turn activates transcription factors AP-1 and the silent information regulator sirtuin 1 (SIRT1), ultimately resulting in anti-inflammatory effects in RA (Boutet et al., 2017).