Parallel inflammasome activation through the NOD-like receptor protein 3 (NLRP3) (Jäger et al., 2021) and absent in melanoma 2 (AIM2) (Cho et al., 2020) platforms in macrophages induces the caspase-1-dependent cleavage of pro-IL-1β and pro-IL-18, which, coupled with gasdermin D-mediated pyroptosis, amplifies the inflammatory response (Tseng et al., 2023). Here, GSDMD is linked to melanoma.