They were also effective in reducing blood pressure in both rats with spontaneous hypertension and mice with angiotensin II (Ang II)-induced hypertension via enhanced vasodilation (Xiao et al., 2016; Liu et al., 2017; Hei et al., 2020; Wu et al., 2020; Zhang et al., 2020; Cheng et al., 2021; Long et al., 2021; Long et al.,2024; Chen et al., 2022;Reinhart et al., 2023). Here, AGT is linked to hypertensive disorder.