TP53 and hepatocellular carcinoma: This finding indicate that Polyphyllin VII has the potential to serve as a promising therapeutic agent for hepatocellular carcinoma (HCC).Hong et al. found that polyphyllin I inhibits tumor growth and induces apoptosis of nasopharyngeal carcinoma cells both in vitro and in vivo by downregulating lncRNA-ROR, which subsequently upregulates the P53 signaling pathway (Hong et al., 2019).