HGF and cancer: However, dysregulated activation of HGF/c-MET axis contributes to the development and progression of numerous human cancers, such as gastroesophageal adenocarcinoma, cholangiocarcinoma, colon cancer, renal cell carcinoma, glioblastomas, and lung cancer, among others (Catenacci et al., 2017; Heo et al., 2017; Gayyed et al., 2015; Peltola et al., 2017).