IL1B and acne: The results show that Clin-Gel and GM-Clin-MN can reduce the expression of pro-inflammatory factors IL-1β and MMP-2 in acne lesions, increase the expression of anti-inflammatory factor IL-10, and GM-Clin-MN has a significantly better effect (p < 0.05), indicating that GM-Clin-MN has a significant inhibitory effect on the acne inflammation induced by acne C. acnes.