Although the physiological roles of ANO1 are diverse, ranging from chloride ion secretion to oncogenesis (Liu et al., 2015; Seo et al., 2020a; b; Seo et al., 2016), targeting ANO1 channel function and diminishing its protein expression have shown therapeutic potential in various cancer cells (Park et al., 2023; Seo et al., 2020a; Seo et al., 2017). The gene discussed is ANO1; the disease is cancer.