Although recent studies demonstrated that CPP protected the mitochondrial membrane integrity of the sheep sperm after preservation at 4°C (Wang et al., 2024), CPP may inhibit hepatocellular carcinoma growth and reestablish the immune balance (Chen et al., 2024; Tang et al., 2021; Li et al., 2024), and CPP increased NAD+, NAD+/NADH, and PGC-1α related to NAD+, thus partially recovering ATP (Li et al., 2024; Hu et al., 2021), it is still unclear whether CPP can also achieve the “Qi-invigoration” through mitochondrial protection in TCM theory. Here, PPARGC1A is linked to hepatocellular carcinoma.