CDK4 and cancer: Furthermore, the occurrence of CVAEs is associated with multiple factors, such as age, basic cardiovascular and metabolic conditions, and medications, etc. (Wilcox et al., 2024) In terms the factors of age, aging impacts the activity of CDK4/6i by disrupting cell cycle regulation and is compounded by its association with patient comorbidities, consequently elevating the risk of CVAEs linked to cancer treatment (Battisti et al., 2018).