These cells have the ability to promote the repair of articular tissue and influence the expression of cytokines IL-8 and -1β, and serve as a source of intracellular signaling peptides, such as platelet-derived growth factor (PDGF), transforming growth factor-β (TGF-β), and vascular endothelial growth factor (VEGF).6, 7Thus, orthobiologic injections can be an excellent option in the treatment of gonarthrosis. Here, VEGFA is linked to osteoarthritis, knee.