Here our results showed that BAT regional endothelium-specific Sirt3 loss not only resulted in vascular rarefaction but also promoted BAT whitening and obesity progression, emphasizing a critical role of BAT endothelial cells in modulating overall metabolism and suggesting that endothelial SIRT3 could be an efficient therapeutic target in modulating angiogenesis and adiposity. This evidence concerns the gene SIRT3 and obesity disorder.