Magnoflorine was found to promote Parkin/PINK1-mediated mitochondrial autophagy, thereby inhibiting NLRP3/Caspase-1-mediated pyroptosis, ultimately decreasing tubular cell steatosis, lipid deposition, tubular dilation, and glomerular fibrosis in chronic kidney disease 40. The gene discussed is NLRP3; the disease is steatosis.