Additionally, treatment of PANC-1 cells with conditioned medium from primary CAFs with POSTN knockdown (pCAF-shPOSTN CM) significantly reduced cell proliferation and colony formation compared to treatment with medium from control CAFs (pCAF-shNC CM), indicating that POSTN is essential for the tumor-promoting effects of CAFs (Figure 7H, L). Here, POSTN is linked to neoplasm.