RGS5 and neoplasm: The results identified two major trajectories: RGS5+ fibroblasts and MYH11+ fibroblasts acted as progenitors, whereas STEAP4+ fibroblasts and Tumor-like fibroblasts represented transitional states, terminally evolving into ECM-remodeling fibroblasts or C7+ fibroblasts (Figure 3A-D, Figure S6A-C).