Remarkable was the decrease of the glioma associated signature of astrocytes (Lgals3, S100 A11, Lgfbpl1 and Nupr1) after RT 64 and of transcripts (Cd74, ApoE e Lyz2) associated with neurodegeneration in oligodendrocytes 65, Supplementary data 9. Here, APOE is linked to central nervous system cancer.