Curcumin, a natural product extracted from the rhizome of the turmeric plant (Curcuma longa) 199, induces HSF1 trimerization 200, promotes its nuclear translocation 201, and enhances the DNA binding capacity, leading to increased HSP70 expression in human colorectal carcinoma 200 and HeLa cells (Table 2) 201 . This evidence concerns the gene HSF1 and colorectal carcinoma.