During the early stage of sepsis, NK cells are activated by cytokines in the circulation, and subsequently secrete other cytokines such as interferon (IFN)-γ, tumour necrosis factor α (TNF-α), further activating other immune cells (macrophages, neutrophils, and dendritic cells), amplifying the inflammatory response, ultimately leading to multiple organ failure 41. This evidence concerns the gene TNF and Sepsis.