STAT1 and bacterial infectious disease: For example, in mice with bacterial infection induced by Escherichia coli and Group A Streptococcus, the use of Asialo-GM1 antibodies to eliminate NK cells decreased the expression of nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription 1 (STAT1), as well as the expression of pro-inflammatory cytokines such as INF-γ, IL-12, and IL-6 in heart, liver, kidney, and lung, ultimately improving the survival rate of septic mice 43, 44.