Recent studies have also shown that LIM domain kinase 1 (LIMK1), a serine/threonine kinase, which controls actin polymerization by phosphorylation and inactivation of cofilin, Activation of RhoA/ROCK signaling pathway induces inflammatory response, oxidative stress, apoptosis and cardiac remodeling in HF rats, and this process is negatively regulated by miR-93143. This evidence concerns the gene LIMK1 and hydrops fetalis.