Exercise-induced cardiac hypertrophy preconditioning can reverse TAC-induced cardiac fibrosis in HF mice and reduce apoptosis and oxidative stress by activating NRF2 and downstream signal transduction genes, suggesting that exercise-induced cardiac hypertrophy preconditioning may be a promising strategy for the prevention and treatment of cardiac fibrosis233. The gene discussed is NFE2L2; the disease is cardiac hypertrophy.