Advanced glycation end products (AGEs) activate the NF-κB pathway via the RAGE receptor, leading to the release of TNF-α, IL-6, and IL-1β, while excessive mitochondrial ROS generation further activates the NLRP3 inflammasome, exacerbating myocardial fibrosis and apoptosis247. The gene discussed is NLRP3; the disease is Myocardial fibrosis.