We then detected the mRNA expression of m6A methyltransferases (METTL3, METTL14, and WTAP) and demethyltransferases (FTO and ALKBH5) and found that METTL3 and FTO mRNA expression was upregulated in Pb-induced nephropathy compared with controls (Figure 1E). This evidence concerns the gene ALKBH5 and kidney disorder.