ACE2 and Anxiety: Additionally, studies on CRH-Angiotensin-converting enzyme 2 (ACE2) KI (ACE2 KI mice are genetically engineered to overexpress ACE2 under the ROSA26 promoter, with Cre-LoxP-mediated restriction to CRH-synthesizing cells) and wild type (WT) mice have shown that overexpression of ACE2 in CRH cells (derived from CRH-ACE2KI mice) inhibits HPA axis activity by decreasing CRH synthesis, resulting in reduced anxiety-like behavior122.