CLC and mesothelioma: Moreover, eosinophil-derived Charcot-Leyden crystal protein/galectin-10 (CLC-P/Gal10) has been implicated in chemoresistance in mesothelioma, where elevated expression correlates with poor prognosis; importantly, anti-eosinophil therapies have been shown to restore chemosensitivity in preclinical models (54).