Another study has shown that a short-term HFD induces the clustering of FLT3 receptors within LR on the membrane of HSCs, thereby enhancing the downstream JAK3/STAT3 signaling pathway and subsequently leading to a decrease in the content of primitive HSCs and an increase in the incidence rate of acute myeloid leukemia (AML) in a mixed lineage leukemia (MLL-AF9) knock-in mouse model (43). The gene discussed is KMT2A; the disease is acute myeloid leukemia.