APC and gastric cancer: In GCs, the top 10 mutated genes were TP53 (59%), HER2 (19%), LRP1B (16%), CDH1 (14%), ARID1A (13%), PIK3CA (11%), APC (9%), ATM (7%), KMT2C (6%), and PREX2 (6%) (Figure 2F) which might play an important role in the biological processes of GC.