To verify the effect of miRNAs on B7-H3 protein expression in breast cancer, Nygren selected 20 different miRNAs, and the study found that 13 of them (miR-214, miR-363*, miR-326, miR-940, miR-29c, miR-665, miR-34b*, miR-708, miR-601, miR-124a, miR-380-5p, miR-885-3p, and miR-593) can directly bind to the 3′-UTR of B7-H3 (24). The gene discussed is CD276; the disease is breast cancer.