Shi discovered that in the study of the mechanism of brain metastasis in triple-negative breast cancer (TNBC), UBE2T promotes B7-H3 expression by directly binding to and ubiquitinating CDC24 (Cell Division Cycle 42), a GTPase that aids in cell structure remodeling, cell migration, cell cycle regulation, and signal transduction, thereby influencing breast cancer progression (36). This evidence concerns the gene CD276 and breast cancer.