In addition to miRNA regulation, the overexpression of immunoglobulin-like transcript 4 (ILT4) in non-small cell lung cancer (NSCLC) cells activates the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway, leading to increased expression of B7-H3 protein (38). This evidence concerns the gene CD276 and non-small cell lung carcinoma.