First, the phenotype of CB-iNK T cells was exclusively CD4+ and enriched in potentially regulatory CD4+CD25+FoxP3+ iNK T cells, while AD-iNK T cells contained varying frequencies of CD4+ iNK T cells with large donor-to-donor variation and reciprocal portions of CD8α-CD4- iNK T cells (Figure 1A). This evidence concerns the gene CD4 and Alzheimer disease.