Highly regulated sites were identified in MAPK pathway, autophagy signaling, viral entry. Differential activation of EIF2AK2 during infection by two viruses may contribute to different growth kinetics of the two viruses. Interplay between Phosphorylation and Ubiquitination can be found on individual host protein (e.g., EGFR). The gene discussed is EIF2AK2; the disease is infection.