Additionally, in tuberculosis (TB) patients, increased numbers of IL-12Rβ2+, WSX-1+, and gp130+ cells have been observed (98), suggesting that the IL-12Rβ2 and WSX-1/gp130 signaling pathways may play important roles in the immune response to TB, offering potential targets for novel therapeutic strategies. The gene discussed is IL6ST; the disease is tuberculosis.