LGI1 and autoimmune encephalitis: Anti-VGKC-complex-positive but anti-LGI1/CASPR2 negative patients may present with autoimmune encephalitis (AE), also reported in several non-autoimmune diseases, including Creutzfeldt–Jakob disease and multiple system atrophy with limited response to immunotherapy and poor correlation between clinical data and serial antibody levels (2).