SOAT1 and autoimmune disease: However, dysregulation of JAK/STAT signaling may also be implicated in the pathogenesis of inflammatory and autoimmune diseases (61), and JAK inhibitors are successfully used in the treatment of rheumatoid arthritis, inflammatory bowel disease, alopecia areata, multiple sclerosis, Sjögren’s syndrome, Behçet’s syndrome and vasculitis (62).