CD8A and neoplasm: Another study showed that treatment with herpes simplex 1-based OV expressing human IL-15/IL-15Rα sushi domain fusion protein (OV-IL15C), and EGFR CAR-NK cells, was able to synergistically suppress tumor growth in a glioblastoma mouse model, while also leading to increased survival and enhanced infiltration and activation of NK and CD8+ T cells (138).