CAT and hyperinsulinemic hypoglycemia, familial, 4: Similarly, GSH deficiency leads to increased vulnerability to oxidative stress, which is essential for tumor progression and metastasis.113,114 The current study revealed that the BTHP administration mitigated the expression of the hepatic and renal oxidative stress biomarker MDA while significantly elevating the expression of different antioxidant biomarkers in both tissues (catalase, SOD, GSH) compared to those in the control EAC-treated group.