Recently, our group reported the synthesis and cytotoxic activity of a set of novel 1,3-thiazole analogs.24 Among the examined compounds, 2-(1-(2-(4-(4-bromophenyl)thiazol-2-yl)hydrazinylidene)ethyl)phenol (BTHP) exhibited potential antiproliferative activity toward MDA-MB-231 and MCF-7 breast cancer cells, which was associated with its ability to target VEGFR-2 (Fig. 1). This evidence concerns the gene KDR and breast cancer.