The anti-aging gene Klotho is closely related to the hypothalamic-pituitary-ovarian axis and plays a key role in the development of reproductive diseases, participating in the regulation of fibroblast growth factor-Klotho endocrine system dysfunction, the accumulation of oxidative stress, and the inhibition of autophagy, which ultimately affects follicular ontogeny, development, ovulation, or atresia (162). The gene discussed is KL; the disease is reproductive system disorder.