TNF and diabetic kidney disease: Imbalances in several pro-inflammatory and anti-inflammatory cytokines have been reported to be associated with the development of DKD, including memory B cells, gamma delta T cells, mononuclear phagocytic cells (MNPs), neutrophils, platelets, tumor necrosis factor alpha (TNF-α), 8-Oxo-7,8-dihydro-2-deoxyguanosine(8oxodG), interleukin 6 (IL-6), and C-reactive protein (CRP) (20, 32–34).