NPHS1 and focal segmental glomerulosclerosis: In MCD there is a subtype of patients believed to have autoantibodies targeting nephrin of the slit diaphragm in the glomerular basement membrane, yet the majority of patients have other circulating factors due to T cell and B cell dysfunction, on the other hand patients with FSGS have not shown any specific circulating factors that podocytopathy can be attributed to [14-17].