Another question of interest that scientists raised and that we found to be useful for the purpose of this review is the interaction between low-grade chronic inflammation and apolipoprotein E (ApoE) genotype and its association with the development of AD. In this study, Tao Q et al. measured the genotype and concentrations of ApoE, C-reactive protein (CRP), a biomarker for low-grade inflammation, and the risk of AD. Here, APOE is linked to Alzheimer disease.