In the study of CSF markers related to neuroinflammation and cerebrovascular changes, data were analyzed from various associations correlating CSF biomarkers (YKL-40, interleukin (IL)-6, IL-7, IL-8, IL-15, interferon-g-induced protein 10 (IP-10), monocyte chemoattractant protein 1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular adhesion molecule 1 (VCAM-1), placental growth factor (PIGF), and FMS-related tyrosine kinase 1 (Flt-1)) with amyloid pathology, tau, gray matter atrophy, and AD progression. The gene discussed is CCL2; the disease is Alzheimer disease.