PLAT and ischemic stroke: The Japanese stroke guidelines allow administration of recombinant tissue-type plasminogen activator (rt-PA) to patients with hyperacute ischemic stroke with concomitant myocardial infarction if eligibility criteria are met, e.g., within four and a half hours of onset, no history of major bleeding, no hypersensitivity to therapeutic agents, no acute aortic dissection or bleeding complications, no persistent hypertension after antihypertensive therapy, no hyperglycemia or hypoglycemia, no thrombocytopenia, no abnormal coagulation capacity, and no extensive early ischemic changes [1].