The AUC for IL-Iβ was 0.80, and the cut-off value was > 47.2 pg/ml, with higher sensitivity (87.32 %) but lower specificity (61.54 %) than ESR and CRP. The results of the present study suggest that IL-1β may have an essential role in the diagnosis of IBD. Here, ESR1 is linked to irritable bowel syndrome.