INS and obesity due to melanocortin 4 receptor deficiency: They contribute to the balance and control of important body functions and systems such as metabolism, the cardiovascular system, and inflammatory and immunological processes [9]. The dysregulation of adipokines associated with obesity negatively affects many body systems, including energy metabolism and insulin sensitivity, predisposing children with obesity to cardiometabolic disease, nonalcoholic fatty liver disease, and autoimmune diseases [10].