found that the high expression of fibrillin-1 (FBN1) in advanced GC and its succinylation modification prevented its degradation by MMPs and activated the TGF-β1 and intracellular PI3K/Akt pathways to promote peritoneal fibrosis and tumor cell adhesion (21–23). The gene discussed is TGFB1; the disease is Peritoneal Fibrosis.