Recent studies also demonstrate that metformin can trigger ferroptosis in HCC cells via pathways involving ATF4/STAT3 signaling or suppression of the p62–Keap1–Nrf2 antioxidant axis, thereby enhancing sensitivity to chemotherapeutic agents such as sorafenib (11, 12, (13). The gene discussed is KEAP1; the disease is hepatocellular carcinoma.